Lund University

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Water in Medicine

Lund University Faculty of Medicine

The Faculty of Medicine is one of eight faculties at Lund University. The Faculty of Medicine, in close cooperation with agents within public healthcare and medicine, contributes to increasing knowledge of high relevance to human health. This is done through education and research of the highest quality in cooperation with wider society. The Faculty encompasses 2,800 full-time students enrolled in 8 degree programmes, as well as 1200 graduate students and 1800 employees.

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Prevention of cardiometabolic disease through increased water intake and inhibition of vasopressin secretion

Vasopressin (VP), also called antidiuretic hormone, is the main hormone regulating body water balance, increasing at low water intake and decreasing at high water intake. We have shown that high plasma concentration of VP (measured by the stable vasopressin marker “copeptin”) independently predicts both diabetes and cardiovascular disease (ref 1-2) and subjects with high VP also typically have insulin resistance, abdominal obesity and hypertension (ref 3-4). In animals we have shown that suppression of VP with high water intake prevents insulin resistance and liver steatosi (ref 5). In humans, we will randomize 1000 subjects with high VP indicating high diabetes risk (copeptin > 6.5 pmol/L in females and >10.7 pmol/L in males) to either extra supplementation with 1.5 L of water (hydration intervention) for one year or control to test if the hydration intervention significantly reduces risk of diabetes.

In summary and conclusion, given the links between high VP and risk of cardiometabolic disease, hydration – which lowers VP- has emerged as a new preventive intervention easily applicable in the population.

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Olle Melander,
Professor of Internal Medicine

Phone: +46704546820  

Page Manager:


Olle Melander

Phone: +46704546820