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Prevention of cardiometabolic disease through increased water intake and inhibition of vasopressin secretion
Vasopressin (VP), also called antidiuretic hormone, is the main hormone regulating body water balance, increasing at low water intake and decreasing at high water intake. We have shown that high plasma concentration of VP (measured by the stable vasopressin marker “copeptin”) independently predicts both diabetes and cardiovascular disease (ref 1-2) and subjects with high VP also typically have insulin resistance, abdominal obesity and hypertension (ref 3-4). In animals we have shown that suppression of VP with high water intake prevents insulin resistance and liver steatosi (ref 5). In humans, we will randomize 1000 subjects with high VP indicating high diabetes risk (copeptin > 6.5 pmol/L in females and >10.7 pmol/L in males) to either extra supplementation with 1.5 L of water (hydration intervention) for one year or control to test if the hydration intervention significantly reduces risk of diabetes.
In summary and conclusion, given the links between high VP and risk of cardiometabolic disease, hydration – which lowers VP- has emerged as a new preventive intervention easily applicable in the population.
Professor of Internal Medicine